The settings in the appearance tab allow you to configure the behaviour of the Fred window.

Ctrl + Alt + Space: a shortcut key combination to make the Fred application window appear.
Keep Fred on top: keeps the Fred window on top of all application windows. This will allow you to drag and drop files from another application directly into the Fred window. Show in taskbar: presents a Fred tab in the Windows taskbar, not only in the system tray. Right mouse click on the icon will provide a command menu.
Delete local copy of document after upload: when selected the source copy of the file (from Explorer or Outlook) will be removed when uploaded into Fred.